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treat osteogenesis imperfecta

Stem cell & gene therapy to treat osteogenesis imperfecta: hype or hope

Pascale V Guillot from University College London, Elizabeth Garrett Anderson Institute for Women’s Health, explains stem cell and gene therapy to treat osteogenesis imperfecta, but is this hype or hope?
eye health

Eye health: Testing the safety of stem cell therapy for age-related macular degeneration

Kapil Bharti, PhD, Senior Investigator and Head of the Ocular and Stem Cell Translational Research Section at the National Eye Institute (NEI), explains testing the safety of a stem cell therapy for age-related macular degeneration in this special focus on eye health.
Figure: Generation of engineered heart tissues (Left) and a cardiac organoid (Right) derived from iPSCs. Left: Scale bar: 500 μm Right: White: Troponin T2 (cardiomyocytes), Green: GFP (fibroblasts), Red: Fibronectin, Blue: Nuclei. Scale bar: 50 μm - treatments for cardiac ailments

The role of stem cell-derived tissues in novel treatments for cardiac ailments

Curbs on animal testing mean human tissues derived from induced pluripotent stem cells offer a promising platform in discovering novel treatments for cardiac ailments.
Abs Lactobacillus Bulgaricus Bacteria

Stem cell therapy shows promise for hirschsprung disease

A potential new treatment avenue has appeared for individuals suffering from Hirschsprung disease, a rare condition affecting the large intestine.
Image: © Alena Butusava | iStock

BRAV3 Project: Cardiac regenerative medicine

Prof Felipe Prósper, Head of Department, and Dr Manuel Mazo, from the University of Navarra & Clínica Universidad de Navarra, shares his expertise in cardiovascular diseases, focusing on the work of the BRAV3 project, which includes research in cardiac regenerative medicine.
Unhappy person having a headache after physical injury at home

Treatment of migraines: Minimally invasive surgery, regenerative approach and botox

Giorgio Pietramaggiori and Saja Scherer, MD, from the Global Medical Institute, describe a revolution in the treatment of migraines: minimally invasive surgery, a regenerative approach and Botox.
Robotic screening platform for T cell growth Photo: SINTEF/Geir Mogen

T cells successfully fighting cancer

Else Marit Inderberg and Sébastien Wälchli from Oslo University Hospital explore what we need to know about T cells successfully fighting cancer.
Vaccine Coronavirus COVID-19 on Conveyor Belt

Learning from the COVID-19 Pandemic: Next-generation universal vaccines and immunotherapeutic research

With the COVID-19 pandemic behind us, we need to focus on universal vaccines and/or immunotherapeutic strategies and technologies to tackle ongoing endemic infections with SARS-CoV2, influenza, and RSV and prepare for any future pandemics, says Dr Babita Agrawal.
Creative image of embryonic stem cells

Cells possess a rapid decision-making system beyond DNA

Scientists at Moffitt Cancer Center have revealed a hidden layer of cellular intelligence that questions the traditional understanding of how cells operate.
Figure 1: Abnormal pain response in IBD and Endometriosis.

Therapeutic potential of the endocannabinoid system to treat chronic pain in inflammatory disease

Pharma researchers Julie Blaising and Philip Smith from F. Hoffmann-La Roche Ltd. discuss the endocannabinoid system as a pathway to treat inflammatory diseases such as Inflammatory Bowel Disease (IBD) and endometriosis.
scientific experiment

Potential infertility treatment: Skin cells transformed into viable eggs

A new technique by researchers at Oregon Health & Science University (OHSU) could change the infertility treatment .
Figure 1: The central nervous system (CNS) is protected from mechanical injury by the skull (A) and from chemical noxious agents by the blood-brain barrier (B, C). The latter consists of the endothelial barrier in most parts of the CNS (B) and the tanycytic barrier in the hypothalamus (C). We develop gene vectors transducing endothelial cells and tanycytes to treat genetic and non-genetic diseases of the brain.

Bridging brain barriers for gene therapy

Reflecting on the challenges in treating brain diseases, this article explores ways to transduce the blood-brain barrier as well as the critical role of tanycytes as a target for gene therapy vectors.
Medical MRI Scan on digital screen

Predicting improved response to lung cancer immunotherapy

Researchers have identified 140 genes that could change how non-small cell lung cancer (NSCLC) patients are treated with immunotherapy and low-dose radiation.

Photodynamic therapy and immune response in solid tumours

Photodynamic therapy can stimulate a person’s own immune system to better recognise – and fight – cancer tumours, say Mary Potasek, PhD and Karl Beeson, PhD of Simphotek and Theresa M Busch, PhD of the Department of Radiation Oncology, University of Pennsylvania.
Medical illustration series about abstract human.The nervous system.

Hydrogen therapy for liver surgery: Current insights and future prospects in ischemia-reperfusion injury

Prof. Giovanni Brandi1,2 and Dr. Simona Tavolari1 of the 1 Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 2Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy, discuss ischemia-reperfusion injury in hepatic surgery, and the potential to prevent it through hydrogen-therapy.
Colored Genetic Code DNA Molecule Structure

Personalized medicine: “Tyranny of the gene”

Dr Priya Hays, Ph.D., CEO/Science Writer at Hays Documentation Specialists, LLC, responds to “Tyranny of the Gene.” Is personalized medicine a threat to public health? Not really, but yes, it’s an argument for price controls and perhaps more regulations; we hear.
Low-Res_T-Cell Machine_9860

Rapid cell production for cancer treatment achieved by new machine

A new method for quickly growing cancer-killing white blood cells can potentially enhance the accessibility of immunotherapy.
Old Asian senior man feel pain, ache, hurt at knee while standing and sitting at home, osteoarthritis concept

Knee health promotion and cell therapy for knee osteoarthritis

Shaw-Ruey Lyu, Professor from Dalin Tzu-Chi Hospital, Tzu-Chi University, says that the knee health promotion option and cell therapy are a perfect combination for knee osteoarthritis.
Figure 1: Potential employment of hydrogen therapy for cancer treatment. Hydrogen administration can exert antitumoral effects by different molecular mechanisms, including the regulation of intracellular ROS production, the reduction of acute/chronic inflammation in damaged tissues, the modulation of immune response, and a better selectivity towards cancer cells than normal cells, which associates with a good safety profile of this treatment.

Hydrogen therapy: An emerging therapeutic strategy in cancer treatment?

Professor Giovanni Brandi (1,2) and Dr Simona Tavolari (1,2) from the University of Bologna discuss findings from preclinical and clinical studies that highlight the potential of hydrogen therapy in cancer treatment.
Brain activity,Human brain damage,Neural network,Artificial intelligence and idea concept

Innovative gene therapy approaches for brain tumour-related epilepsy

Professor Mark Cunningham and Dr Kate Connor from Trinity College Dublin discuss the burden of brain tumour-related epilepsy and why novel therapies are urgently needed to improve the quality of life for those affected.

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