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Targeting the brain for the treatment of type 1 diabetes
Michael W. Schwartz, MD, explains the role played by the brain as a cause of elevated blood sugar and related metabolic derangements in type 1 diabetes, and how therapeutic targeting of this brain system can eliminate the need for insulin therapy in animal models.
Sudden death is the most catastrophic manifestation of heart disease
Any disease affecting the heart muscle (“myocardium”) is a potential cause of sudden cardiac death. Such diseases include recovery following a heart attack (myocardial infarct “MI”) and diseases, such as Hypertrophic and Dilated Cardiomyopathies (HCM, DCM) together with a host of rarer diseases.
Defining Electromagnetic Hypersensitivity (EHS)
Michael Bevington, Chair of Trustees at Electrosensitivity UK, examines the history of Electromagnetic Hypersensitivity (EHS) over the past 275 years, highlighting key 18th-century discoveries and early reports of health issues related to electromagnetic fields (EMFs).
Chronic pain and healthcare education in Canada: Bridging the divide
Hansel Lui from the Michael G. DeGroote Institute for Pain Research and Care discusses inadequacies in healthcare education regarding chronic pain management in Canada and opportunities to close these gaps.
Tracing evolution’s blueprint: Minimal genome life and the engineering of synthetic endosymbiosis
Roksana Riddle and Christopher H. Contag from Michigan State University discuss the concept of endosymbiosis, how it has evolved, and present strategies to engineering endosymbionts and their applications in developing innovative therapies.
CYP genes and haplotypes in personalised medicine
Brian Tait, Chief Scientific Officer at Haplomic Technologies Pty Ltd, focuses here on CYP genes, haplotypes, and their applications in personalised medicine.
Revolutionising indoor air quality to stop pandemics with Germicidal Ultraviolet (GUV) technology
Indoor air quality is a silent public health crisis, harbouring pathogens that contribute to billions of illnesses annually. Addressing this requires urgent attention, and Germicidal Ultraviolet (GUV) technology offers a powerful solution to combat airborne threats.
Can premenstrual symptoms help improve women’s healthcare?
Professor Belinda Pletzer from Paris Lodron University of Salzburg explores if the assessment of premenstrual symptoms can help improve women’s healthcare.
Healthy aging: How science and daily habits preserve brain function
Key nutrients like omega-3 fatty acids, curcumin, and NAD+ are important for maintaining cognitive function, but their effective delivery to the brain is hindered by the blood-brain barrier (BBB) and age-related declines in nutrient transport. Dr Rebecca Crews and Heather Makar explore the importance of overcoming these delivery challenges to enhance strategies for cognitive longevity and healthy aging.
Training your genome
Founder and President of InsideOutBio, Alan Herbert, explores the evolving understanding of genome information storage, and the significance of repetitive sequences called flipons in genome training. These flipons can alter their shape without breaking DNA and are vital in cell biology, especially in responding to environmental stress.
AI-driven innovations in GPCR ligand synthesis for treating inflammatory diseases
This article explores the significance of G Protein-Coupled Receptors (GPCRs) in therapeutic drug development and strategies for advancing GPCR-targeted therapies, including the use of agonists, antagonists, biased agonism, and allosteric modulators.
Unlocking the brain: Pioneering psychiatric genomics at the University of Arizona
Psychiatric disorders challenge us deeply. At the University of Arizona, researchers dissect their molecular roots, focusing on genomics. They aim to decode miRNA’s role in conditions like depression, using advanced analysis to forge a path towards personalized mental health care. Find out more in this exclusive Q&A.
Estimating the impact of cigarette smoking on life expectancy from 1950 to 2000
In this study, Theodore R. Holford from the Department of Biostatistics at the Yale University School of Public Health estimates the impact of cigarette smoking on life expectancy between 1950 and 2000.
The challenge of determining the health risks of low-dose chemical exposures
Rebecca J. Wilson and Pamela J. Lein, explore whether the dose makes the poison or not. Here, they discuss the challenges of determining health risks associated with low-dose chemical exposures.
Lives and money: Understanding the true cost of sepsis in Canada
Kali Barrett, Victoria Chechulina, and Fatima Sheikh discuss the economic burden of sepsis in Canada and the economic rationale for implementing coordinated, national strategies to combat this often-overlooked disease.
Optimizing outcomes: The role of surgical technique and intraoperative factors in cochlear implant performance
Variability in cochlear implant performance remains a significant challenge for clinicians and patients. Contributors from Washington University School of Medicine investigate how surgical techniques and intraoperative adjustments can be refined to further optimize cochlear implant outcomes.
Novel treatments offer hope for neglected tropical diseases
This interview with Professors Achim Hoerauf and Marc Hübner explores their groundbreaking work, focusing on the development of novel drugs and the importance of collaborative partnerships in tackling these devastating diseases.
Microbiomes should be incorporated into The One Health Joint Plan of Action
The One Health Joint Plan of Action was created by major international organizations to tackle global health issues related to human, animal, plant, and environmental health. This article emphasizes the importance of integrating microbiomes into this framework to enhance health systems and prevention strategies.
Quantitative reasoning in higher education: The 5C Model
Quantitative reasoning enhances and lengthens lives. Professor Gregory Foley of Ohio University discusses how his team is improving QR instruction in U.S. higher education.
Ultrasound neuromodulation for treatment-resistant depression: A case for deep brain stimulation
Tiago Costa from Delft University of Technology discusses why ultrasound neuromodulation has significant potential to transform the treatment of depression.
