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Beautiful young woman riding on the metro wearing a facemask to avoid an infectious disease - COVID-19 lifestyle concepts

Post-pandemic MERS-CoV still presents risks

Darryl Falzarano, Research Scientist at the Vaccine and Infectious Disease Organization (VIDO), discusses potential solutions that are needed to tackle the coronavirus known as MERS-CoV.
Elderly care image

Reducing restraint on residents in Hong Kong care home settings

Individuals from the Jockey Club Centre for Positive Ageing discuss reducing using restraint on residents in Hong Kong care home settings.
Figure 1: Immunofluorescent image of OVCAR3 cells in culture showing that cells are at different stages of the cell cycle. P53 (green) is nuclear in all cells that are not dividing, including PGCCs that are multinuclear (a) and (b). PGCC during abnormal cytokinesis (c). P53 is redistributed in cells undergoing normal mitosis where the condensed chromosomes are either at the midbody (d) or are undergoing cytokinesis (e). (1)

Controlling ovarian cancer: An introduction to detection and treatment

With current strategies proving inadequate, what needs to be done is to further the research into detecting, treating, and controlling ovarian cancer.
Figure 1: Potential employment of hydrogen therapy for cancer treatment. Hydrogen administration can exert antitumoral effects by different molecular mechanisms, including the regulation of intracellular ROS production, the reduction of acute/chronic inflammation in damaged tissues, the modulation of immune response, and a better selectivity towards cancer cells than normal cells, which associates with a good safety profile of this treatment.

Hydrogen therapy: An emerging therapeutic strategy in cancer treatment?

Professor Giovanni Brandi (1,2) and Dr Simona Tavolari (1,2) from the University of Bologna discuss findings from preclinical and clinical studies that highlight the potential of hydrogen therapy in cancer treatment.
3d illustration of molecule model. Science background with molecules and atoms

Probing the individuality of cells and molecules

Sotaro Uemura, Professor at the University of Tokyo, probes the individuality of cells and molecules.

Options for stroke survivors: From stroke to conventional therapy

Discovery of novel treatment options for stroke survivors – requirements for implanted systems.
A Hydractinia (type of marine invertebrate) colony rejecting another because they are genetically unrelated

The successes and challenges of organ transplantation

Fadi G. Lakkis, Professor of Surgery at the University of Pittsburgh, charts the successes and challenges of organ transplantation.
Brain activity,Human brain damage,Neural network,Artificial intelligence and idea concept

Innovative gene therapy approaches for brain tumour-related epilepsy

Professor Mark Cunningham and Dr Kate Connor from Trinity College Dublin discuss the burden of brain tumour-related epilepsy and why novel therapies are urgently needed to improve the quality of life for those affected.
Senior man feeling pain at home

Major depressive disorder: Brain signals as biomarkers for depression

Tiago Costa from Delft University of Technology explores the potential of neuroimaging techniques, specifically non-invasive electroencephalography (EEG), in detecting biomarkers for depression.
Doctor and Assistant surgeons work for rescue patient in operation room at hospital, emergency case, surgery, medical technology, health care cancer and disease treatment concept, I2, molecular iodine

Dispersing the misconceptions of molecular iodine in medical uses

There are many uses for molecular iodine (I2) for infection prevention. Dispelling misconceptions about its toxicity, Dr. Jack Kessler, Chief Scientist at I2Pure, discusses the reality of I2 across medical indications and seeks to grow its application.
Enamel surface

Keep your teeth for life: The tartar challenge

Dr. Marcel Donnet and Dr. Dixit Neha discuss how GBT can overcome the challenge of tartar removal to preserve your teeth for life.
Lijuan Yuan with Gn pig jpg

Gnotobiotic pig models: Illuminating the enigma of human norovirus infection and immunity

Dr Lijuan Yuan and her team have studied human noroviruses (HuNoV) in gnotobiotic pigs for over 15 years. Here, she explains how such research is advancing our understanding of HuNoV pathogenesis, infectivity, and immunity.
Skin tissue cells and fat tissue cells ,dermis and adipocytes

Microbiome of the skin: The good and the bad

Chronic wounds are a significant burden to patients and health systems; Manuela Martins-Green from the University of California tells us how her research in understanding the dynamics of wound healing could aid new approaches to wound care.
Pills On Yellow Background, symbolising drug repositioning

Can we do drug repositioning without disease gene expression?

Chuo University’s Professor Y-h. Taguchi examines the application of cutting-edge single-cell-based measurements in drug repositioning.
Figure 1. Left ventricular stroke volume relationship to morbidity and mortality in patients ≥12-years-old

Age-related changes in cardiomyopathic phenotype in patients with barth syndrome

With current treatment options for BTHS cardiomyopathic phenotype focused predominantly on alleviating symptoms, Dr Hani N. Sabbah, Director of Cardiovascular Research at Henry Ford Health, explores the potential of more targeted treatment approaches.

Decoding the brain’s role in preventing and recovering from knee injuries

Dustin Grooms, Professor of Clinical Neuroscience at Ohio University, tells us about his research on the brain’s role in shaping injury-risk movement patterns and how this knowledge could aid rehabilitation practices and the development of new therapies to mitigate the risk of knee injuries.
Figure 1: Immunomodulatory therapies are effective during the relapsing-remitting phase of MS, when immune cells are found in active lesions, but fail to ameliorate progressive decline and irreversible clinical disability. Increased axonal injury correlates with lack of immune cell infiltration but sustained activation of resident CNS glial cells in the progressive phase. These pathological findings are consistent with MRI imaging studies demonstrating virtually no new lesions occurring during progressive MS. Additionally, at the time of MS diagnosis there is evidence of prior lesion activity by MRI imaging supporting that the future development of neuroprotective strategies should be administered in combination with immunomodulatory therapies.

Targeting the central nervous system: The future of therapeutic strategies for MS

Tara M. DeSilva from the Department of Neurosciences, Cleveland Clinic, looks at the future of therapeutic strategies for MS, focusing on targeting the central nervous system.
Microscopic photo of a professionally prepared slide demonstrating Plasma cell myeloma from bone marrow aspirate. Wright Giemsa stain.

Developing novel therapies for childhood cancers

Dr Peter J Houghton from Greehey Children’s Cancer Research Institute discusses the obstacles in developing new treatments for childhood cancers and new approaches in preclinical testing.
A beautiful and strong athletic young woman working hard cross fitness workout in low light gym working with medicine ball.

The mechanisms and benefits of exercise

At Wayne State University, Robert Wessells and his team are making significant strides in identifying potential exercise mediators or mimetics that could help mitigate pathologies resulting from prolonged sedentary periods.
Scientific analysis of Alzheimer's disease in hospital, conceptual image

Lecanemab and other treatments: Glimmers of hope for alzheimer’s patients

Effective treatments for amyloid-associated neurological diseases are desperately needed; H. Robert Guy, CEO of Amyloid Research Consultants, talks us through the obstacles and opportunities associated with structure-based drug design.

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