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Sepsis Canada

Making preclinical sepsis research stronger, faster, and more responsive to patients

Sepsis represents a significant global burden. The National Preclinical Sepsis Platform (NPSP) is leading vital sepsis research, informing policy, driving innovation, and ultimately saving lives.
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Seasonality and climate change: Challenges for physical activity in older adults

Research indicates seasonal variations in physical activity levels among adults in different climates due to temperature and humidity. Climate change’s increasing extreme weather may significantly affect physical activity in older adults already struggling to meet activity guidelines. Isabelle J. Dionne from the Université de Sherbrooke explains.
Image: © SolarCloud | iStock

Hormonal contraceptives and women’s mental health – A long-term perspective

Belinda Pletzer of the University of Salzburg discusses the importance of researching the mental health effects of hormonal contraceptives and the need to identify women at risk for adverse mood reactions before they start hormonal contraception.

Engineering interkingdom communication for next-generation therapeutic approaches

Brian Snyder and Christopher H. Contag, from Michigan State University, discuss engineering interkingdom communication, which is not for palace intrigue, but for next-generation therapeutic approaches they argue.

Adipose tissue: A treasure trove of stem cells for regenerative medicine

Adipose tissue, commonly known as fat, has long been considered a mere energy reservoir. However, recent discoveries have revolutionized our understanding of this tissue, placing it at the heart of advances in stem cells and regenerative medicine.
Photography of incense stick smoke.

Modeling cigarette smoking exposure in subsets of the population

Understanding and acknowledging various factors that impact cigarette smoking and exposure is critical when creating public health interventions to curb tobacco use. Here, Theodore R. Holford from Yale University discusses the impact of different approaches to tobacco control.
A female patient is refusing to take a shot from her doctor. She is holding her hands in front of her doctor as if defending herself from the syringe and the needle.

Vaccine hesitancy and the challenge of successful scientific communication

Drawing on personal experiences and public discourse, Dr. Klaus Eyer, an Associate Professor at Aarhus University, explores the challenges of communicating about vaccine science to address vaccine hesitancy.
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Understanding and predicting the intergenerational transmission of mental illness

The FAMILY consortium aims to improve the lives of mentally ill persons and their families by focusing on understanding the mechanisms of intergenerational transmission of mental illness from parent to child.
Figure 1: Three different non-genetically encoded scaffolds regulate cellular responses. The interactions between them are normally kept in check to ensure that cells remain healthy and functional, with arrows indicating positive interactions and dotted lines with a bar at one end representing inhibitory events. The Z-RNAs expressed from the genome will cause inflammatory cell death when interferon induces high levels of ZBP1 (as indicated by the scarlet shading). That response eliminates virally infected cells, other aged cells that no longer function normally, and those inflamed cells that support the growth of malignancies.

Cellular scaffolding: Crowdsourcing cellular responses in health and disease

In this article, Dr Alan Herbert discusses how different types of cellular scaffolds interact and impact the risk of diseases, citing the example of Z-RNAs pushing cells to inflammatory states in tumors and autoimmune conditions, setting the stage for new therapeutics.

The sociology of bridge: Sport recognition for mind sports

The game of contract bridge, as we know it today, originated in the 20th century – but what lies ahead for bridge as a mind sport? Professor Samantha Punch, the academic behind “Bridge: A MindSport For All”, provides the answer.
Neuron cells system - 3d rendered image of Neuron cell network on black background. Hologram view interconnected neurons cells with electrical pulses. Conceptual medical image. Glowing synapse. Healthcare concept.

Timely diagnosis and intervention for people with dementia

Jockey Club Centre for Positive Ageing experts highlight the importance of timely diagnosis and intervention for people with dementia.
Brain activity,Human brain damage,Neural network,Artificial intelligence and idea concept

A novel avenue to explore in the treatment of dementia

A collaborative project between the University of South Florida and The Healthy Aging Company is exploring how a new biological entity called ALF5755 could be a candidate drug for the treatment of dementia and Alzheimer’s disease.
Figure 1: Electrocochleography-total response (ECochG-TR) measured at the round window prior to cochlear implant insertion (RW-ECochG-TR) shows a weak correlation with performance in noise (AzBio +10 dB signal-to-noise ratio). Similarly, the MoCA score, a measure of cognitive function, also exhibits a weak correlation with performance in noise. However, a multivariate model incorporating both cochlear health (ECochG-TR), cognition (MoCA score), and their interaction (product of ECochG-TR and MoCA) explains 46.0% of the variability in noise performance. This finding suggests that while good cochlear health is necessary for strong performance in noise, it is not sufficient on its own – it must be complemented by adequate cognitive function.

Cognitive function and electrode mapping’s role in cochlear implant performance

Amit Walia, Matthew Shew and Craig A. Buchman from Washington University School of Medicine, detail the role of cognitive function and electrode mapping in cochlear implant performance.
Purple dna

Personalized medicine beyond cancer: Impact on other diseases

With a focus on type 2 diabetes and Parkinson’s disease, Dr Priya Hays explores how personalized medicine approaches are impacting the development of therapies for other chronic conditions beyond cancer.
vaccinations in Africa, vaccines, vaccines and biologics

Catalysing vaccines and biologics manufacturing in Africa

Professor Faith Osier, Director of the Chanjo Hub at Imperial College London, shares her vision for vaccines and biologics manufacturing in Africa to secure lives and livelihoods and drive economic growth.
Senior sport people having fun after exercising in yoga class outdoor at park city - Fitness joyful Elderly lifestyle

Identifying potential exercise mimetics that deliver the benefits of exercise

Robert Wessells, Associate Professor at Wayne State University, discusses his research on identifying potential exercise mediators or mimetics to deliver the benefits of exercise to less mobile individuals and help reduce the global disease burden.

Persistent anti-vaxxers and pandemic-induced new anti-vaxxers

Read this analysis of persistent anti-vaxxers and pandemic-induced new anti-vaxxers by Fujio Toriumi, Professor at the University of Tokyo in Japan.
Music concert instruments silhouette

Tuning into musicians’ wellbeing: Research on music performance anxiety (MPA)

The Music and Mental Health Research Clinic (MMHRC) at the University of Ottawa’s Institute of Mental Health Research (IMHR) at The Royal is investigating how to reduce music performance anxiety (MPA) and the benefits of specific coping strategies for musicians.

Harnessing hybrid molecules for drug development

Stoyanka Nikolova, Professor from Paisii Hilendarski Plovdiv University, discusses the potential of harnessing hybrid molecules for drug development and their possible application in addressing the clinical challenge of irritable bowel syndrome.
Brain food nutrition concept as a group of nutritious nuts fish vegetables and berries rich in omega-3 fatty acids with vitamins and minerals for mind and memory health with 3D illustration elements.

Early intervention in eating disorders

Tracey Wade from Flinders University, charts an implementation approach to early intervention in eating disorders.

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