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A game that poses a challenge to artificial intelligence

Steven J. Brams, hailing from New York University, unveils a game that poses a challenge to artificial intelligence.
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A promising approach to preventing developmental dyslexia

David Mather, an Independent Researcher at the University of Victoria, has a promising approach to preventing developmental dyslexia. Discover more here.
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Innovative packaging design enhances vaccine accessibility for developing countries

Unither Pharmaceuticals is dedicated to innovating and expanding capacity to provide equitable vaccine accessibility in developing countries and enhance preparedness for future pandemics. Here, they explain how the Euroject® device can support their goals.
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Healthy aging: A novel therapy to reverse age-related damage

What if we could turn back the clock on age-associated dysfunctions by using a therapy that not only treats symptoms but acts to correct the underlying pathology and restores cells to normal function? Lori A. Birder and Edwin K. Jackson from the University of Pittsburgh School of Medicine, explain how this could be a possibility.

Flipons: The discovery of Z-DNA and soft-wired genomes

Alan Herbert, Founder and President of InsideOutBio, discusses alternative DNA conformations and understanding of their biological functions.
Figure 1. Work experience support and advice (Source NRAS WorkMatters 2017), juvenile-onset rheumatic and musculoskeletal diseases

The impact of juvenile onset rheumatic and musculoskeletal diseases on education, vocation and employment

Professor Suzanne Verstappen discusses the impact and challenges associated with juvenile-onset rheumatic and musculoskeletal diseases when navigating education and employment.
Figure 1. Gene expression regulated by tissue-specific regulatory elements/enhancers

How the dark genome enlightens the molecular mechanisms of diseases

In this article, Antoinette van Ouwerkerk and Salvatore Spicuglia from INSERM highlight the significance of regulatory variants within the non-coding genome – often referred to as the ‘dark genome’ – in influencing gene expression and disease.
Figure 1: a) Nanotextured spinal implants now in over 30,000 humans with no cases of failure [2]. Such implants are being commercialized by Nanovis. b) Nanosensors now being used to detect the presence of bacteria, inflammatory cells, or bone-forming cells on implants. Such nanosensors can communicate to handheld devices and can respond in real-time to reverse adverse events. Such sensors have been implanted in sheep for up to 12 weeks showing the ability to promote bone growth.

Opinion: What are the barriers to innovation in medicine?

Thomas J. Webster, PhD provides a firsthand account of the obstacles hindering innovation in medicine, covering publishing, conferences, politics, funding, universities, and industry.
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The future of AVS, dizziness, and vertigo in emergency departments Part iii: A tyranny...

In the third article of this five-part series, Dr Millie Nakatsuka discusses the impact of isolation on health equity and the medical decision-making for emergency presentations of acute vestibular syndrome (AVS)
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The challenge of generating lasting mucosal anti-viral sterilising immunity

Achieving sterilising immunity is often challenging and sometimes even impossible. This article gives a glimpse into the concepts behind and highlights some recent advances and challenges.
Figure: Generation of engineered heart tissues (Left) and a cardiac organoid (Right) derived from iPSCs. Left: Scale bar: 500 μm Right: White: Troponin T2 (cardiomyocytes), Green: GFP (fibroblasts), Red: Fibronectin, Blue: Nuclei. Scale bar: 50 μm - treatments for cardiac ailments

The role of stem cell-derived tissues in novel treatments for cardiac ailments

Curbs on animal testing mean human tissues derived from induced pluripotent stem cells offer a promising platform in discovering novel treatments for cardiac ailments.

Safer and more effective use of opioids

The Pain PLUS literature surveillance service demonstrates the importance of high-quality literature to support decision-making and practice for the use of opioids.
Figure 1: Box plots of performance measures showing all data points of 250 patients at three months across AzBio in Quiet, AzBio in Background Noise, and CNC in Quiet. All measurements were made with the CI-only condition. There was substantial variability across all speech recognition measures among CI recipients.

Predicting cochlear implant performance: Impact of demographic, audiologic, surgical factors, and cochlear health

Amit Walia, Matt Shew and Craig A. Buchman from Washington University School of Medicine, explain the challenges of understanding variables or factors informing CI performance and how this can be addressed.
Professional female doctor examines results of mammography screening procedure using computer. Mammogram scans of breast tissues displayed on PC screen. Breast cancer prevention. Hospital or clinic.

Artificial intelligence (AI) in mammographic screening in Norway

BreastScreen Norway discusses how the results from their screening programme for early breast cancer detection can influence future artificial intelligence to streamline early breast cancer detection.
Table 1: Change in neuropsychological performance on the flame composite and the individual factors over two years in people with amnestic MCI (n = 548) (3)

Innovation in clinical trials in brain health: Computerised assessment and remote clinical trials

New clinical trials in brain health require innovative methodologies for targeted recruitment and longitudinal assessment. Professor Anne Corbett outlines how her team’s PROTECT portfolio can overcome challenges in trials of cognitive health interventions, offering solutions for intelligent trial design.
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The ethical and legal challenges of cell donation for brain organoid research

Ethical and legal concerns raised by the use of human biological materials, especially cells from adult donors and foetal tissues, must be thoroughly examined.
Stethoscope on nurse & doctor coat backgroundStethoscope on nurse & doctor coat background: SONY A7

A call for intersectionality in gerontological nursing education

Addressing the triple jeopardy of ageism, sexism and racism within healthcare systems is crucial to ensuring equitable health outcomes for all older people, write Professor Jordana Salma, Professor Sherry Dahlke and Professor Kathleen Hunter of the Faculty of Nursing at the University of Alberta.
Image: © Ivan Bajic | iStock

Detoxification: The science behind social media claims of detox health benefits

Jessie R. Badley and Pamela J. Lein from the University of California, Davis, explain the science behind detoxification and the claims of detox health benefits in social media and the deception associated with it.
RESTART intervention study design

RESTART Project Q&A: Empowering healthy aging

In this Q&A, a team from the RESTART project explores their groundbreaking intervention model designed to empower people to embrace healthier lifestyles as they near retirement.
CorTec Brain Interchange Implant for Stroke Treatment

Stroke rehabilitation milestone, neurological conditions and future therapy

Martin Schuettler, Chief Technology Officer of CorTec GmbH, walks us through a groundbreaking achievement in the development of future therapies for neurological conditions like stroke.

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