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Flipons: The discovery of Z-DNA and soft-wired genomes
Alan Herbert, Founder and President of InsideOutBio, discusses alternative DNA conformations and understanding of their biological functions.
The impact of juvenile onset rheumatic and musculoskeletal diseases on education, vocation and employment
Professor Suzanne Verstappen discusses the impact and challenges associated with juvenile-onset rheumatic and musculoskeletal diseases when navigating education and employment.
How the dark genome enlightens the molecular mechanisms of diseases
In this article, Antoinette van Ouwerkerk and Salvatore Spicuglia from INSERM highlight the significance of regulatory variants within the non-coding genome – often referred to as the ‘dark genome’ – in influencing gene expression and disease.
![Figure 1: a) Nanotextured spinal implants now in over 30,000 humans with no cases of failure [2]. Such implants are being commercialized by Nanovis. b) Nanosensors now being used to detect the presence of bacteria, inflammatory cells, or bone-forming cells on implants. Such nanosensors can communicate to handheld devices and can respond in real-time to reverse adverse events. Such sensors have been implanted in sheep for up to 12 weeks showing the ability to promote bone growth.](https://www.openaccessgovernment.org/wp-content/uploads/2024/07/Screenshot-2024-07-04-at-09.19.27-218x150.png "Opinion: What are the barriers to innovation in medicine?")
Opinion: What are the barriers to innovation in medicine?
Thomas J. Webster, PhD provides a firsthand account of the obstacles hindering innovation in medicine, covering publishing, conferences, politics, funding, universities, and industry.
The future of AVS, dizziness, and vertigo in emergency departments Part iii: A tyranny...
In the third article of this five-part series, Dr Millie Nakatsuka discusses the impact of isolation on health equity and the medical decision-making for emergency presentations of acute vestibular syndrome (AVS)
The challenge of generating lasting mucosal anti-viral sterilising immunity
Achieving sterilising immunity is often challenging and sometimes even impossible. This article gives a glimpse into the concepts behind and highlights some recent advances and challenges.
The role of stem cell-derived tissues in novel treatments for cardiac ailments
Curbs on animal testing mean human tissues derived from induced pluripotent stem cells offer a promising platform in discovering novel treatments for cardiac ailments.
Safer and more effective use of opioids
The Pain PLUS literature surveillance service demonstrates the importance of high-quality literature to support decision-making and practice for the use of opioids.
Predicting cochlear implant performance: Impact of demographic, audiologic, surgical factors, and cochlear health
Amit Walia, Matt Shew and Craig A. Buchman from Washington University School of Medicine, explain the challenges of understanding variables or factors informing CI performance and how this can be addressed.
Artificial intelligence (AI) in mammographic screening in Norway
BreastScreen Norway discusses how the results from their screening programme for early breast cancer detection can influence future artificial intelligence to streamline early breast cancer detection.
Innovation in clinical trials in brain health: Computerised assessment and remote clinical trials
New clinical trials in brain health require innovative methodologies for targeted recruitment and longitudinal assessment. Professor Anne Corbett outlines how her team’s PROTECT portfolio can overcome challenges in trials of cognitive health interventions, offering solutions for intelligent trial design.
The ethical and legal challenges of cell donation for brain organoid research
Ethical and legal concerns raised by the use of human biological materials, especially cells from adult donors and foetal tissues, must be thoroughly examined.
A call for intersectionality in gerontological nursing education
Addressing the triple jeopardy of ageism, sexism and racism within healthcare systems is crucial to ensuring equitable health outcomes for all older people, write Professor Jordana Salma, Professor Sherry Dahlke and Professor Kathleen Hunter of the Faculty of Nursing at the University of Alberta.
Detoxification: The science behind social media claims of detox health benefits
Jessie R. Badley and Pamela J. Lein from the University of California, Davis, explain the science behind detoxification and the claims of detox health benefits in social media and the deception associated with it.
RESTART Project Q&A: Empowering healthy aging
In this Q&A, a team from the RESTART project explores their groundbreaking intervention model designed to empower people to embrace healthier lifestyles as they near retirement.
Stroke rehabilitation milestone, neurological conditions and future therapy
Martin Schuettler, Chief Technology Officer of CorTec GmbH, walks us through a groundbreaking achievement in the development of future therapies for neurological conditions like stroke.
Risk factors for cannabis use in young people
With cannabis use among young people on the rise, Ronan Fleury, Prof Bobby Smyth and Prof Mary Cannon. discuss the mental and physical impacts and the importance of understanding the risk factors.
From selfish silo to collaborative culture – embracing data-enabled cancer research
Aedin Culhane and Mark Lawler, Co-Leads of the eHealth Hub for Cancer, reflect on their data-enabled cancer research journeys, how their collaborative team science approach has reaped significant dividends in cancer research and policy and how the hub is inducing a paradigm shift in how health data are deployed on the island of Ireland.
What imaging reveals about engineered endosymbionts
Ashley V. Makela and Christopher H. Contag from the Institute for Quantitative Health Science and Engineering, walk us through watching living therapeutics in action, including what imaging reveals about engineered endosymbionts.
Prolonged lactation: Preventing obesity since infancy
Dr Vincent Prevot and Professors Markus Schwaninger and Ruben Nogueiras explain the significance of the perinatal maternal lifestyle, specifically prolonged lactation, in shielding offspring from chronic disease.
