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Antibody binding to human cell receptors is a crucial aspect of the immune response and plays a fundamental role in various physiological processes, including immune defense, signaling, and regulation of cellular functions. Antibodies, also known as immunoglobulins, are proteins produced by the immune system in response to the presence of foreign substances, such as pathogens or abnormal cells.

High-resolution snapshots of antibody repertoires as potential correlates of protection

Klaus Eyer from ETH Zurich describes high-resolution snapshots of antibody repertoires as potential correlates of protection.
Figure 1: Global mpox case trends from 2022 to 2023 across all WHO regions. Source: 2022-23 Mpox (Monkeypox) Outbreak: Global Trends (shinyapps.io)

MPOX: Research priorities for threat reduction

Concerted efforts are needed to close knowledge gaps around mpox to improve preparedness and response efforts for this neglected disease.
Sepsis, bacteria in blood. 3D illustration showing rod-shaped bacteria in blood with red blood cells and leukocytes

Sepsis and the killer platelets

Dermot Cox BSc, PG Dip Ed, PhD, Pharmacology Lead from the School of Pharmacy and Biomolecular Sciences – RCSI University of Medicine & Health Sciences, discusses sepsis and the killer platelets.

Revolutionising disease detection: The emergence of non-invasive VOC breathomics

Breathomics marks a revolutionary approach to disease detection by analyzing the chemical composition of exhaled breath.

Mongolia and the One Health Approach

Mongolia’s unique ecosystems and cultures come with an equally unique set of wildlife management challenges.
Vertigo dizzynes

The future of AVS, dizziness and vertigo in emergency departments: Part I. Towards a...

In this first of five articles, Dr Millie Nakatsuka discusses the socio-economic implications associated with the diagnosis of acute vestibular syndrome and why more cost-effective and sustainable approaches are needed.
beautiful little girl with her dog on the snow in winter

Nutritional management of aging pets

Morgan A. Key from Hill’s Pet Nutrition outlines the changes associated with aging pets and how nutrition can help.
Close up side profile view face of African sad thoughtful teenager girl sit on sofa at home looking into distance feels unhappy, first unrequited love, teen relation problem, break up, worries concept

Building resilience: Key to protecting adolescent mental health

Essi Viding, Pasco Fearon, Tom Wu, Alexander Lloyd, Laura Lucas, Roslyn Law, and Jaime Smith discuss new approaches to preventing adolescent mental health problems from emerging.
asbestos chrysotile fibers that cause lung disease, COPD, lung cancer, mesothelioma

Lessons from Libby: Understanding the impact of asbestos exposure

Jean C. Pfau, Scientific Consultant at the Center for Asbestos Related Disease, shares the devasting story of asbestos exposure occurring in a Rocky Mountain town of Montana and the critical lessons that can be learned from this event.
Abstract Lactobacillus Bulgaricus Bacteria - 3d rendered microbiology image. Medical research, health-care concept. SEM (TEM)scanning view

Sepsis Canada: Building a national research network for sepsis awareness

Sepsis is a life-threatening condition estimated to affect 49 million people annually worldwide; yet it is not widely understood. In this article, we hear how Sepsis Canada is working to promote sepsis awareness through supporting research, public education, and cross-disciplinary training.
Image: © OGphoto | iStock

Chronic organ damage: Understanding fibrosis

Fibrosis was once considered irreversible, resulting from chronic organ damage; Ken-Ichi Kobayashi from Notre Dame Seishin University tells us why the possibility of treatment to reverse the disease is gaining attention.
Figure 1: Sankey diagram showing 2 categories of psychopathology and transitions between categories (Healy et al, 2022)

The long shadow of childhood mental health problems

Dr Niamh Dooley and Professor Mary Cannon explore what young adult life looks like for individuals who had mental health problems as children.
Neural cells network on a dark background - 3d rendered image of the neural cell network image on a black background. Glowing synapse. Displaying neurons and the neural network. Electrical impulses in neural networks.

Exploring HER-096: A novel approach to Parkinson’s Disease

Parkinson’s disease, a progressive neurodegenerative disorder, poses significant challenges for both patients and researchers. In a recent interview with Henri Huttunen from Herantis Pharma Plc, we delved into the intricacies of their potential novel disease-modifying therapy, HER-096.
Figure 1. Two routes of brain infection by which SARS-CoV-2 may enter the hypothalamus and infect GnRH neurons. The virus attaches to and enters cells harbouring surface receptors such as ACE2 (black spanner-like symbol) or NRP1 (red cylinder). GnRH neurons exhibit both, which might increase their vulnerability. A. The haematological route, whereby the respiratory virus (white spheres) makes its way through the lungs into the bloodstream (dark red), and thence into the median eminence (ME), a part of the hypothalamus that harbours ”fenestrated” or leaky blood vessels. The virus may affect a number of different cell types locally, including GnRH neurons (green), whose secretory terminals approach the fenestrated vessels, and tanycytes (grey), whose processes control this secretion and also transport other bloodborne hormones and other substances into the brain. Once inside the brain ventricles (V), fluid-filled canals within the brain, the virus can also travel to other areas. B. The olfactory route, whereby the virus enters the olfactory bulb (OB) of the brain directly from the nose across the bony cribriform plate by means of nerve bundles or infected olfactory neurons and other cell types. GnRH neurons, which are born in the nasal epithelium during the embryonic period and migrate into the brain along these nerve bundles to their final positions, still maintain a connection with their birthplace, and could be thus be infected directly or indirectly through olfactory neurons or other cells. GnRH neurons also project to parts of the brain involved in higher functions such as cognition, potentially contributing to long-COVID symptoms such as “brain fog”.

Brain infection by SARS-CoV-2: Lifelong consequences

The WATCH team, founded to elucidate the role played by specialized brain cells called tanycytes in various physiological processes, has been investigating how and where the SARS-CoV-2 virus infects the brain, and some long-term consequences of this neuro-invasion.
A distraught senior Asian woman feeling unwell, suffering from pain in leg while sitting on sofa in the living room at home

A wonder therapy for knee osteoarthritis

Professor Shaw-Ruey Lyu from the Dalin Tzu-Chi Hospital discusses the benefits of arthroscopic cartilage regeneration facilitating procedure (ACRFP) as an alternative to traditional methods of treating knee OA.
Fig. 1 White matter hyperintensities (illustrated in blue) in a representative image of the human brain (A) are primarily found near ventricles. The neuronal cell bodies are found mainly in the cortex (gray matter) and myelinated neuronal axons in the white matter (B). Figure created using BioRender.

What is the link between white matter lesions and neurodegeneration?

Tara M. DeSilva from the Department of Neurosciences, Cleveland Clinic, examines the link between white matter lesions and neurodegeneration.
An old couple walking in the park, elderly people, primary care

Primary care and medical education for Japan’s ageing population

Prof Junji Haruta from Keio University highlights Japan’s ageing population, focusing on challenges and innovations in primary care, plus medical education.
View of the synapses. Brain connections. Neurons and synapses. Communication and cerebral stimulus. Neural network circuit, degenerative diseases, Parkinson. 3d render

Treatments for ADHD: Can neurotherapies help treat children and adults?

Professor Katya Rubia from the Institute of Psychiatry, Psychology, and Neurosciences at King’s College London discusses the potential of non-invasive brain therapies, including neurofeedback, as treatments for ADHD.
Cropped shot of a senior woman holding hands with a nurse

Addressing ageism in healthcare through gerontological nursing

Sherry Dahlke, Associate Professor at the Faculty of Nursing, University of Alberta, discusses the impact of ageism in healthcare and why gerontological nursing education is vital for improving awareness and patient care.

Role for retired internists in rural, underserved communities

Richard J Santen MD, Emeritus Professor of Medicine, Davison of Endocrinology and Metabolism, University of Virginia, Charlottesville, Virginia, U.S., charts the role of retired internists in rural, underserved communities, including diabetes telemedicine.
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