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The microbiome and aging: Unlocking new frontiers in healthy longevity
Research conducted by the USF Microbiomes Institute and the MiaGB Consortium is uncovering the significant link between microbial communities and host biology. This understanding could lead to new therapies for age-related conditions. Shalini Jain, Christian Brechot, and Hariom Yadav provide further insights.
![Figure 1. Systemic immune responses elicited by oral dmLT-saponin combinations compared to injected vaccines (A) Cryo-electron microscopy (cryo-EM) image of the dmLT and saponin formulation demonstrating the formation of acid-stable micelle particles upon the addition of saponin to dmLT. (B) Preclinical evaluation of systemic serum IgG and IgA antibody responses following prime/boost vaccination. Antibody levels against the microbial protein antigen included in the vaccination were assessed two weeks post-final vaccination in immunized mice. Groups were stratified by vaccination route (intramuscular [IM] or sublingual [SL]) and adjuvant formulation (dmLT [D] and/or saponin [S]). Comparisons with unvaccinated controls (white bars) are shown. Statistical significance between groups is indicated (*P < 0.05), with the SL D+S group achieving the best IgG and IgA responses to vaccine antigen.](https://www.openaccessgovernment.org/wp-content/uploads/2025/01/Figure-01-218x150.jpg "New strategies for an old problem – Oral vaccines research")
New strategies for an old problem – Oral vaccines research
Despite their advantages, oral vaccines encounter several challenges. Professor Elizabeth Norton from Tulane University discusses how her team is addressing these issues and their research on developing and testing dmLT and saponin combination adjuvants.
Single chromosome sequencing to obtain genetic phase (haplotyping)
Brian Tait, Chief Scientific Officer at Haplomic Technologies Pty Ltd, examines single chromosome sequencing to obtain genetic phase (haplotyping).
A legacy of medicine and biodiversity: Protecting the cinchona tree
The endangered Cinchona officinalis, native to the Andean foothills, produced the world’s first anti-malarial drug. Augusta Cueva-Agila explains why it is crucial to conserve this species and how conservation efforts can be implemented.
Predicting cochlear implant performance: Moving beyond single biomarkers and leveraging artificial intelligence
Matthew Shew, Amit Walia, and Craig A. Buchman highlight that the significant variability in speech perception among cochlear implant users can be addressed by using a multi- faceted approach that incorporates emerging technologies like machine learning and artificial intelligence to improve outcome prediction models.
Neuroengineering with engineered endosymbionts
Christopher H. Contag and Ahmed A. Zarea from Michigan State University’s Institute for Quantitative Health Science and Engineering explore therapeutic approaches to neurodegenerative diseases using a novel strategy based on engineered endosymbionts systems that could revolutionize patient care.
The role of host condition and environment on infection outcome
Brian P. Lazzaro from Cornell University discusses his research on the factors influencing immune response and infection outcome, drawing on powerful experimental systems, such as Drosophila melanogaster as a model host, to gain a deeper understanding of foundational biological processes.
Exposomics: A shift in biomedical research with potential to improve human health
Recent advances in exposomics offer an exciting opportunity to comprehensively catalog human exposures and link them to biological responses determining health and disease. Pamela J. Lein, Ph.D. from the University of California, tells us more.
Cell biology research: The mystery of cholesterol homeostasis
Kazumitsu Ueda, PhD from Kyoto University, WPI-iCeMS, unveils the mystery of cholesterol homeostasis in this cell biology research focus.
Helping biodiversity conservation with modelling
Professor Guillaume Blanchet from Université de Sherbrooke discusses how modelling can aid in the conservation of biodiversity.
Primate exposure to anthropogenic pollutants: An overlooked conservation concern
Michael Wasserman of Indiana University discusses research on wild primate exposure to endocrine disruptors, such as pesticides, flame retardants, and phytoestrogens.
An ancient therapy modernized for Clostridioides Difficile therapy
Clostridioides difficile is a type of bacteria that often affects people who have been taking antibiotics. Glenn S. Tillotson of GST Micro LLC explains how live biotherapeutic products have shown promise as a safe and effective treatment to help restore the normal gut microbiome.
![Figure 1: Ratios of the concentrations of Sodium ions [Na+] and Potassium ions [K+] in water on land and in the sea vs in living cells and in blood.](https://www.openaccessgovernment.org/wp-content/uploads/2024/12/Fig-1-218x150.png "Is there an elephant in the room of research on the origins of life?")
Is there an elephant in the room of research on the origins of life?
Helen Greenwood Hansma, from the University of California at Santa Barbara, questions if there is an elephant in the room of research when it comes to the origins of life.
Training and citizen engagement to tackle soil health challenges
The ECHO project approach in tackling soil health challenges through soil literacy and citizen engagement.
Asbestos, the pleural cavity, and autoimmune disease
Jean C. Pfau, Ph.D. from the Center for Asbestos-Related Disease and Kinta Serve from Idaho State University, provide their perspective on asbestos, the pleural cavity, and autoimmune disease.
Ciliary biomarkers for vascular health
Ramani Ramchandran, Professor at the Medical College of Wisconsin, investigates ciliary biomarkers for diagnosing and prognosing vascular health.
Data integration: A key to understanding the biological basis of mental disorders
ses two key advancements in genome-wide association studies (GWAS) and gene expression data to better understand the biological basis of mental disorders.
Membrane biogenesis, nutrient transport, and natural health product characterization
Find out here about Dr. Bakovic, an internationally recognized researcher in membrane biogenesis, nutrient transport, and natural health product characterization.
Understanding T-societies: How patterns shape our lives
Emeritus Professor Magnus S Magnusson explores the unique sudden bio-mathematical self-similarity between human and protein societies and the human explosion: from T-patterns to T-strings and T-societies.
E. coli genomes, big data, and messy biology
Here, David Ussery from the Department of BioMedical Informatics, UAMS, details E. coli genome diversity, big data, and messy biology. New methods, we discover, allow for the comparison of millions of bacterial genomes in a few days and the confident assignment of taxonomic clusters.
