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Figure 1. Two routes of brain infection by which SARS-CoV-2 may enter the hypothalamus and infect GnRH neurons. The virus attaches to and enters cells harbouring surface receptors such as ACE2 (black spanner-like symbol) or NRP1 (red cylinder). GnRH neurons exhibit both, which might increase their vulnerability. A. The haematological route, whereby the respiratory virus (white spheres) makes its way through the lungs into the bloodstream (dark red), and thence into the median eminence (ME), a part of the hypothalamus that harbours ”fenestrated” or leaky blood vessels. The virus may affect a number of different cell types locally, including GnRH neurons (green), whose secretory terminals approach the fenestrated vessels, and tanycytes (grey), whose processes control this secretion and also transport other bloodborne hormones and other substances into the brain. Once inside the brain ventricles (V), fluid-filled canals within the brain, the virus can also travel to other areas. B. The olfactory route, whereby the virus enters the olfactory bulb (OB) of the brain directly from the nose across the bony cribriform plate by means of nerve bundles or infected olfactory neurons and other cell types. GnRH neurons, which are born in the nasal epithelium during the embryonic period and migrate into the brain along these nerve bundles to their final positions, still maintain a connection with their birthplace, and could be thus be infected directly or indirectly through olfactory neurons or other cells. GnRH neurons also project to parts of the brain involved in higher functions such as cognition, potentially contributing to long-COVID symptoms such as “brain fog”.

Brain infection by SARS-CoV-2: Lifelong consequences

The WATCH team, founded to elucidate the role played by specialized brain cells called tanycytes in various physiological processes, has been investigating how and where the SARS-CoV-2 virus infects the brain, and some long-term consequences of this neuro-invasion.
Fig. 1 White matter hyperintensities (illustrated in blue) in a representative image of the human brain (A) are primarily found near ventricles. The neuronal cell bodies are found mainly in the cortex (gray matter) and myelinated neuronal axons in the white matter (B). Figure created using BioRender.

What is the link between white matter lesions and neurodegeneration?

Tara M. DeSilva from the Department of Neurosciences, Cleveland Clinic, examines the link between white matter lesions and neurodegeneration.
View of the synapses. Brain connections. Neurons and synapses. Communication and cerebral stimulus. Neural network circuit, degenerative diseases, Parkinson. 3d render

Treatments for ADHD: Can neurotherapies help treat children and adults?

Professor Katya Rubia from the Institute of Psychiatry, Psychology, and Neurosciences at King’s College London discusses the potential of non-invasive brain therapies, including neurofeedback, as treatments for ADHD.
Panther project, brain injury detection

Advanced brain injury detection and protection

The U.S.-based PANTHER program is pioneering a physics-based approach to TBI for quantitatively and deterministically linking the physics of a head insult to the resulting biological injury response. Christian Franck and Alice Lux Fawzi discuss.
Figure 1. A) A test for AI consciousness B) Integrating AI and biological hemispheres with C) a radically new brain-machine-interface that reads and writes from the surface of dissected axonal bundle (e.g., corpus callosum)

AI consciousness and neuroscientifically plausible “seamless” mind-uploading

Masataka Watanabe, Associate Professor at the University of Tokyo’s School of Engineering, examines a test for AI consciousness. He proposes it as part of a scientific approach to deciphering consciousness that leads to “seamless” mind uploading.

Options for stroke survivors: From stroke to conventional therapy

Discovery of novel treatment options for stroke survivors – requirements for implanted systems.
Futuristic laboratory equipment. Brainwave scanning research on computer screens

Exploring neurological & mental brain disorders in Europe

European Brain Council provides a very helpful update on Brain disorders in Europe – neurological and mental alike.
Abstract blue, mint and pink background with interlaced digital Distorted Motion glitch effect. Futuristic cyberpunk design. Retro futurism, webpunk, rave 80s 90s aesthetic techno neon colors, psychedelic colours

Psychedelic therapies: The case for a new focus in the EU’s mental health care...

Tadeusz Hawrot, Founder and Executive Director of PAREA, states the case for a new focus in the EU’s mental health care approach, that is the underserved area of psychedelic therapies.
Neuron cells system - 3d rendered image of Neuron cell network on black background. Hologram view interconnected neurons cells with electrical pulses. Conceptual medical image. Glowing synapse. Healthcare concept, brain system

CorTec’s Brain Interchange™ system: Revolutionizing brain therapy with closed-loop neuromodulation

CorTec’s Brain Interchange™ system offers closed-loop neuromodulation, revolutionizing brain therapy by precisely adapting treatment based on individual needs.
Close-up medical syringe with a vaccine, BoNT-A injection

Potential implications of cosmetic BoNT-A use on future treatment options for neuromuscular disorders and...

Given the rise in cosmetic procedures involving BoNT-A, cosmetic physician Dr Mary Dingley discusses the therapeutic implications of antibody-induced resistance on future treatment of various conditions, including post-stroke spacticity and pain disorders.
Carbon nano-tubes are twisted to form a yard (bar: 10um)

Recording and decoding neural signals from the vagus nerve

Dominique M Durand, distinguished Professor of Biomedical Engineering, Case Western Reserve University, Cleveland Ohio, USA, discusses the study of neural signals from the vagus nerve.
White brain on white background with copy space - 3D illustration

How brain research is making the benefits of regular exercise accessible to all

Robert Wessells from Wayne State University looks to the brain to understand how the benefits of regular exercise can be delivered to those who are unable to move as easily.
Brain activity,Human brain damage,Neural network,Artificial intelligence and idea concept

Progress in development of disease-modifying treatments in Parkinson’s Disease

Henri Huttunen, Chief Scientific Officer, Herantis Pharma Plc, charts progress in the development of disease-modifying treatments for Parkinson’s disease.
Brain astrocytoma of a human, photomicrograph panorama as seen under the microscope, 200x zoom.

Exploring current and future therapies for childhood astrocytoma

Here, Doctor Peter J Houghton explains current therapies for childhood brain cancer what needs to change to ensure better outcomes for children diagnosed with astrocytoma in the future.
abstact image of a brain used to promote, nonhuman primate brain research

Fostering nonhuman primate (NHP) brain research without animal sacrifice

The MacBrain Resource Center (MBRC) at Yale University School of Medicine is positioning itself at the forefront of innovative ways to provide cost-effective means for scientists to conduct de novo nonhuman primate brain research with extant materials.
Neuron cell close-up view - 3d rendered image of Neuron cell on black background. SEM view interconnected neurons synapses. Abstract structure conceptual medical image. Synapse. Healthcare concept, representing Alzheimer's Disease therapeutics

Beyond amyloid: What’s next for Alzheimers disease therapeutics?

Bradlee Heckmann, PhD, from USF Health Neuroscience Institute, Byrd Alzheimer’s Center & Asha Therapeutics, in this discussion goes beyond amyloid, asking what’s next for Alzheimer’s Disease therapeutics.
African psychologist hold hands of girl patient, close up. Teenage overcome break up, unrequited love. Abortion decision. Psychological therapy, survive personal crisis, individual counselling concept

Updating services for people with younger onset dementia and their caregivers

Researchers from the Jockey Club Centre for Positive Ageing analyse the services available for people with younger onset dementia, looking to improve the lives of those affected and their carers.
White matter refers to areas of the central nervous system that are mainly made up of myelinated axons, also called tracts.Long thought to be passive tissue, white matter affects learning and brain functions, modulating the distribution of action potentials, acting as a relay and coordinating communication between different brain regions

FMRI neurofeedback: Novel interventions for depression

Kymberly Young, an Associate Professor of Psychiatry at the University of Pittsburgh School of Medicine, discusses neurofeedback as a novel non-invasive intervention for depression.
prevent MS, CT scan

Great leaps in multiple sclerosis treatment but the holy grail is still ahead

CEO of MS Australia Rohan Greenland highlights the breakthroughs in treating attacks on the brain and spinal cord in multiple sclerosis (MS). But his sights are set firmly on the great unmet needs: to repair damaged nerves, reverse disability, and ultimately, prevent MS.
psychedelic treatments

Brain health conditions: Excellence in psychedelic treatments

Psychedelic treatments open up an unparalleled window of opportunity, but we need to get ready for their roll-out.

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