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Living with rare genetic disorders: Challenges of EPP and XLP
Kirstine Juhl Belongie discusses the impact, symptoms, and possible treatments related to EPP and XLP, two debilitating disorders that cause extreme pain following exposure to sunlight.
The role of host condition and environment on infection outcome
Brian P. Lazzaro from Cornell University discusses his research on the factors influencing immune response and infection outcome, drawing on powerful experimental systems, such as Drosophila melanogaster as a model host, to gain a deeper understanding of foundational biological processes.
Exposomics: A shift in biomedical research with potential to improve human health
Recent advances in exposomics offer an exciting opportunity to comprehensively catalog human exposures and link them to biological responses determining health and disease. Pamela J. Lein, Ph.D. from the University of California, tells us more.
Cell biology research: The mystery of cholesterol homeostasis
Kazumitsu Ueda, PhD from Kyoto University, WPI-iCeMS, unveils the mystery of cholesterol homeostasis in this cell biology research focus.
Data integration: A key to understanding the biological basis of mental disorders
ses two key advancements in genome-wide association studies (GWAS) and gene expression data to better understand the biological basis of mental disorders.
Understanding T-societies: How patterns shape our lives
Emeritus Professor Magnus S Magnusson explores the unique sudden bio-mathematical self-similarity between human and protein societies and the human explosion: from T-patterns to T-strings and T-societies.
A novel approach to cancer chemotherapy
Richard F. Ludueña, Professor Emeritus at the University of Texas Health San Antonio, discusses his innovative approach to cancer chemotherapy, which could significantly enhance its effectiveness.
Stem cell therapy for osteoarthritis: Functional cartilage regeneration using 3d bioprinting technology
Osteoarthritis presents a significant societal and economic burden. Stina Simonsson from the University of Gothenburg explains how EU-funded projects are using 3D bioprinting to create functional cartilage for OA treatment.
Engineering interkingdom communication for next-generation therapeutic approaches
Brian Snyder and Christopher H. Contag, from Michigan State University, discuss engineering interkingdom communication, which is not for palace intrigue, but for next-generation therapeutic approaches they argue.
Adipose tissue: A treasure trove of stem cells for regenerative medicine
Adipose tissue, commonly known as fat, has long been considered a mere energy reservoir. However, recent discoveries have revolutionized our understanding of this tissue, placing it at the heart of advances in stem cells and regenerative medicine.
Cellular scaffolding: Crowdsourcing cellular responses in health and disease
In this article, Dr Alan Herbert discusses how different types of cellular scaffolds interact and impact the risk of diseases, citing the example of Z-RNAs pushing cells to inflammatory states in tumors and autoimmune conditions, setting the stage for new therapeutics.
Personalized medicine beyond cancer: Impact on other diseases
With a focus on type 2 diabetes and Parkinson’s disease, Dr Priya Hays explores how personalized medicine approaches are impacting the development of therapies for other chronic conditions beyond cancer.
Protecting the human epigenome with nutritional epigenetics intervention programs
Dr Renee J. Dufault, Executive Director at the Food Ingredient and Health Research Institute, explains the significance of nutritional epigenetics in understanding the impact of nutrients and dietary chemicals on gene expression patterns, as well as their role in the development of conditions such as autism and ADHD.
Healthy aging: A novel therapy to reverse age-related damage
What if we could turn back the clock on age-associated dysfunctions by using a therapy that not only treats symptoms but acts to correct the underlying pathology and restores cells to normal function? Lori A. Birder and Edwin K. Jackson from the University of Pittsburgh School of Medicine, explain how this could be a possibility.
Flipons: The discovery of Z-DNA and soft-wired genomes
Alan Herbert, Founder and President of InsideOutBio, discusses alternative DNA conformations and understanding of their biological functions.
How the dark genome enlightens the molecular mechanisms of diseases
In this article, Antoinette van Ouwerkerk and Salvatore Spicuglia from INSERM highlight the significance of regulatory variants within the non-coding genome – often referred to as the ‘dark genome’ – in influencing gene expression and disease.
The challenge of generating lasting mucosal anti-viral sterilising immunity
Achieving sterilising immunity is often challenging and sometimes even impossible. This article gives a glimpse into the concepts behind and highlights some recent advances and challenges.
The role of stem cell-derived tissues in novel treatments for cardiac ailments
Curbs on animal testing mean human tissues derived from induced pluripotent stem cells offer a promising platform in discovering novel treatments for cardiac ailments.
The ethical and legal challenges of cell donation for brain organoid research
Ethical and legal concerns raised by the use of human biological materials, especially cells from adult donors and foetal tissues, must be thoroughly examined.
From selfish silo to collaborative culture – embracing data-enabled cancer research
Aedin Culhane and Mark Lawler, Co-Leads of the eHealth Hub for Cancer, reflect on their data-enabled cancer research journeys, how their collaborative team science approach has reaped significant dividends in cancer research and policy and how the hub is inducing a paradigm shift in how health data are deployed on the island of Ireland.
