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Tracing evolution’s blueprint: Minimal genome life and the engineering of synthetic endosymbiosis
Roksana Riddle and Christopher H. Contag from Michigan State University discuss the concept of endosymbiosis, how it has evolved, and present strategies to engineering endosymbionts and their applications in developing innovative therapies.
CYP genes and haplotypes in personalised medicine
Brian Tait, Chief Scientific Officer at Haplomic Technologies Pty Ltd, focuses here on CYP genes, haplotypes, and their applications in personalised medicine.
Training your genome
Founder and President of InsideOutBio, Alan Herbert, explores the evolving understanding of genome information storage, and the significance of repetitive sequences called flipons in genome training. These flipons can alter their shape without breaking DNA and are vital in cell biology, especially in responding to environmental stress.
AI-driven innovations in GPCR ligand synthesis for treating inflammatory diseases
This article explores the significance of G Protein-Coupled Receptors (GPCRs) in therapeutic drug development and strategies for advancing GPCR-targeted therapies, including the use of agonists, antagonists, biased agonism, and allosteric modulators.
Unlocking the brain: Pioneering psychiatric genomics at the University of Arizona
Psychiatric disorders challenge us deeply. At the University of Arizona, researchers dissect their molecular roots, focusing on genomics. They aim to decode miRNA’s role in conditions like depression, using advanced analysis to forge a path towards personalized mental health care. Find out more in this exclusive Q&A.
Microbiomes should be incorporated into The One Health Joint Plan of Action
The One Health Joint Plan of Action was created by major international organizations to tackle global health issues related to human, animal, plant, and environmental health. This article emphasizes the importance of integrating microbiomes into this framework to enhance health systems and prevention strategies.
Bioinformatics into TB surveillance: A new approach to an ancient foe
David Ussery, a Professor in the Department of BioMedical Informatics at UAMS, and his Ph.D. student Brian Delavan discuss bioinformatics into TB surveillance, presenting a new approach to tackling this ancient foe.
Stem cell exhaustion and its role in healthy aging
Scientist Sarallah Rezazadeh from the Icahn School of Medicine explores the molecular mechanisms behind adult stem cells as we age.
Predicting cancer risk with computational biology
Andrew Teschendorff, Professor at the Chinese Academy of Sciences, is developing computational systems-biological tools to identify cells at risk of turning cancerous.
The microbiome and aging: Unlocking new frontiers in healthy longevity
Research conducted by the USF Microbiomes Institute and the MiaGB Consortium is uncovering the significant link between microbial communities and host biology. This understanding could lead to new therapies for age-related conditions. Shalini Jain, Christian Brechot, and Hariom Yadav provide further insights.
Single chromosome sequencing to obtain genetic phase (haplotyping)
Brian Tait, Chief Scientific Officer at Haplomic Technologies Pty Ltd, examines single chromosome sequencing to obtain genetic phase (haplotyping).
Living with rare genetic disorders: Challenges of EPP and XLP
Kirstine Juhl Belongie discusses the impact, symptoms, and possible treatments related to EPP and XLP, two debilitating disorders that cause extreme pain following exposure to sunlight.
The role of host condition and environment on infection outcome
Brian P. Lazzaro from Cornell University discusses his research on the factors influencing immune response and infection outcome, drawing on powerful experimental systems, such as Drosophila melanogaster as a model host, to gain a deeper understanding of foundational biological processes.
Exposomics: A shift in biomedical research with potential to improve human health
Recent advances in exposomics offer an exciting opportunity to comprehensively catalog human exposures and link them to biological responses determining health and disease. Pamela J. Lein, Ph.D. from the University of California, tells us more.
Cell biology research: The mystery of cholesterol homeostasis
Kazumitsu Ueda, PhD from Kyoto University, WPI-iCeMS, unveils the mystery of cholesterol homeostasis in this cell biology research focus.
Data integration: A key to understanding the biological basis of mental disorders
ses two key advancements in genome-wide association studies (GWAS) and gene expression data to better understand the biological basis of mental disorders.
Understanding T-societies: How patterns shape our lives
Emeritus Professor Magnus S Magnusson explores the unique sudden bio-mathematical self-similarity between human and protein societies and the human explosion: from T-patterns to T-strings and T-societies.
A novel approach to cancer chemotherapy
Richard F. Ludueña, Professor Emeritus at the University of Texas Health San Antonio, discusses his innovative approach to cancer chemotherapy, which could significantly enhance its effectiveness.
Stem cell therapy for osteoarthritis: Functional cartilage regeneration using 3d bioprinting technology
Osteoarthritis presents a significant societal and economic burden. Stina Simonsson from the University of Gothenburg explains how EU-funded projects are using 3D bioprinting to create functional cartilage for OA treatment.
Engineering interkingdom communication for next-generation therapeutic approaches
Brian Snyder and Christopher H. Contag, from Michigan State University, discuss engineering interkingdom communication, which is not for palace intrigue, but for next-generation therapeutic approaches they argue.