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Figure: Generation of engineered heart tissues (Left) and a cardiac organoid (Right) derived from iPSCs. Left: Scale bar: 500 μm Right: White: Troponin T2 (cardiomyocytes), Green: GFP (fibroblasts), Red: Fibronectin, Blue: Nuclei. Scale bar: 50 μm - treatments for cardiac ailments

The role of stem cell-derived tissues in novel treatments for cardiac ailments

Curbs on animal testing mean human tissues derived from induced pluripotent stem cells offer a promising platform in discovering novel treatments for cardiac ailments.
Image: © Alena Butusava | iStock

BRAV3 Project: Cardiac regenerative medicine

Prof Felipe Prósper, Head of Department, and Dr Manuel Mazo, from the University of Navarra & Clínica Universidad de Navarra, shares his expertise in cardiovascular diseases, focusing on the work of the BRAV3 project, which includes research in cardiac regenerative medicine.
Photography of steam.

Cigarette smoking focus: A modeling approach for estimating the impact of health programs

Theodore R. Holford from Yale University charts a modeling approach for estimating the impact of health programs in this cigarette smoking research focus.
Abstract fractal art background which could suggest a neural network, or the nervous system, or other themes of connectivity and biology, neuropathic pain

Treating neuropathic pain and nicotine dependence: Epibatidine derivatives as potential therapeutics

Lance R. McMahon, Ph.D. and Jenny L. Wilkerson, Ph.D. from Texas Tech University Health Sciences Center, describe the search for the magic bullet to treat both neuropathic pain and nicotine dependence using novel epibatidine derivatives as potential therapeutics.
Image: © SolStock| iStock

Tackling physical inactivity and a sedentary lifestyle: Two distinct approaches

Being physically inactive and sedentary are two distinct issues that affect older adults. However, each problem necessitates a unique set of solutions; Professor Isabelle J. Dionne from the Université de Sherbrooke tells us more.
Marathon runners running on city road, large group of runners

Enhancing marathon safety: The role of low-dose aspirin in cardiac arrest prevention

Arthur J. Siegel, Medical Director at MGH Internal Medicine Associates, Belmont, MA, USA tells us how low-dose aspirin can support primary prevention of marathon-related cardiac arrest in middle-aged men with coronary atherosclerosis.
Figure 1. Left ventricular stroke volume relationship to morbidity and mortality in patients ≥12-years-old

Age-related changes in cardiomyopathic phenotype in patients with barth syndrome

With current treatment options for BTHS cardiomyopathic phenotype focused predominantly on alleviating symptoms, Dr Hani N. Sabbah, Director of Cardiovascular Research at Henry Ford Health, explores the potential of more targeted treatment approaches.

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