Professor JoAnne S. Richards’ research career interests have focused on the hormonal regulation of ovarian follicular development by applying molecular approaches and using mutant mouse models.
Having identified genes and signaling pathways that regulate specific stages of ovarian follicular development and ovulation, including the roles of ADAMTS1, TNFAIP6 and PTGS2 in the ovulation process.
While most of the studies have focused on granulosa cells functions, recent studies have shown that androgens impact theca cell functions, especially in relation to PCOS.
Specifically, analyzing and identifying inflammatory events associated with peri-ovulatory events in follicles of PCOS patients undergoing IVF.
These studies have led to our current interest in how androgens control the ovarian follicle and more specifically theca cell functions.
Using a DHT mouse model, we have observed major changes in theca cell morphology, expansion into the stromal compartment and gene expression profiles.
