Drinking during pregnancy, even in low to moderate amounts, can change the baby’s brain structure and delay brain development
MRI study reveals that drinking during pregnancy, even in low to moderate amounts, can change the baby’s brain structure and delay brain development. The results of the study will be presented next week at the annual meeting of the Radiological Society of North America (RSNA).
“Fetal MRI is a highly specialized and safe examination method that allows us to make accurate statements about brain maturation prenatally,” comments study senior author Gregor Kasprian, M.D., associate professor of radiology from the Department of Biomedical Imaging and Image-guided Therapy of the Medical University of Vienna in Austria.
Drinking during pregnancy can cause fetal alcohol spectrum disorders
Alcohol consumption during pregnancy can expose the fetus to a group of conditions called fetal alcohol spectrum disorders. Fetal alcohol spectrum disorders has various implications, including:
- Learning disabilities
- Behavioural problems
- Speech delays
- Language delays
“Unfortunately, many pregnant women are unaware of the influence of alcohol on the fetus during pregnancy,” adds lead author Patric Kienast, M.D., a PhD student in the Department of Biomedical Imaging and Image-Guided Therapy, Division of Neuroradiology and Musculoskeletal Radiology at the Medical University of Vienna.
“Therefore, it is our responsibility not only to do the research but also to actively educate the public about the effects of alcohol on the fetus.”
Analysis of fetuses with prenatal alcohol exposure
For the study, researchers analysed MRI exams of 24 fetuses with prenatal alcohol exposure. The fetuses were between 22 and 36 weeks of gestation at the time of the MRI scan.
Researchers determined alcohol exposure via anonymous surveys of the mothers. The questionnaires used were the Pregnancy Risk Assessment Monitoring System (PRAMS), a surveillance project of the Centers for Disease Control and Prevention and health departments, and the T-ACE Screening Tool, a measurement tool of four questions that identify risk drinking.
In fetuses with alcohol exposure, the fetal total maturation score (fTMS) was significantly lower than in the age-matched controls, and the right superior temporal sulcus (STS) was shallower. The STS is involved in social cognition, audiovisual integration and language perception.
“We found the greatest changes in the temporal brain region and STS,” Dr Kasprian said. “We know that this region, and specifically the formation of the STS, has a great influence on language development during childhood.”
Brain changes were seen in the fetuses even at low levels of alcohol exposure
“Seventeen of 24 mothers drank alcohol relatively infrequently, with average alcohol consumption of less than one alcoholic drink per week,” Dr Kienast said. “Nevertheless, we were able to detect significant changes in these fetuses based on prenatal MRI.”
One alcoholic drink a week can change baby’s brain
Three mothers drank one to three drinks per week, and two mothers drank four to six drinks per week. One mother consumed an average of 14 or more drinks per week. Six mothers also reported at least one binge drinking event (exceeding four drinks on one occasion) during pregnancy.
According to the researchers, delayed fetal brain development could be specifically related to a delayed stage of myelination and less distinct gyrification in the frontal and occipital lobes.
The myelination process is critical to brain and nervous system function. This is because myelin protects nerve cells, allowing them to transmit information faster. Important developmental milestones in infants, such as rolling over, crawling, and language processing, are directly linked to myelination.
Gyrification refers to the formation of the folds of the cerebral cortex. This folding enlarges the surface area of the cortex with limited space in the skull, enabling an increase in cognitive performance. When gyrification is diminished, functionality is reduced.
Pregnant women should strictly avoid alcohol consumption
“Pregnant women should strictly avoid alcohol consumption,” Dr Kienast explains.
“As we show in our study, even low levels of alcohol consumption can lead to structural changes in brain development and delayed brain maturation.”
It is still unknown how these structural changes will affect brain development in these babies after birth.
“To assess this accurately, we need to wait for the children who were examined as fetuses at that time to get a little older so that we can invite them back for further examinations,” Dr Kienast concludes.
“However, we can strongly assume that the changes we discovered contribute to the cognitive and behavioural difficulties that may occur during childhood.”
