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The role of host condition and environment on infection outcome

Brian P. Lazzaro from Cornell University discusses his research on the factors influencing immune response and infection outcome, drawing on powerful experimental systems, such as Drosophila melanogaster as a model host, to gain a deeper understanding of foundational biological processes.
3d illustration of clostridium bacteria

An ancient therapy modernized for Clostridioides Difficile therapy

Clostridioides difficile is a type of bacteria that often affects people who have been taking antibiotics. Glenn S. Tillotson of GST Micro LLC explains how live biotherapeutic products have shown promise as a safe and effective treatment to help restore the normal gut microbiome.
Targeting the endocannabinoid system

Targeting the endocannabinoid system: A promising hope for the treatment of Inflammatory bowel Disease...

Current IBD treatments leave many battling uncomfortable symptoms. The bodies natural endocannabanoid system (ECS) is linked to gut health. By targeting the system, researchers believe they will be able to develop novel treatments that tackle inflammation, diarrhea and lingering discomfort. By focusing on this, researchers believe they will be able to develop treatments that tackle both inflammation and lingering discomfort.
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The importance of accounting for gender differences in cardiovascular disease care

Cardiovascular disease (CVD) is the leading cause of death in women worldwide, highlighting the need for greater awareness and research into sex and gender differences impacting cardiovascular care.
Coronavirus. COVID-19. Copy space. 3D Render

Building global health with lego vaccines

Prof Tuck Seng Wong and Dr Kang Lan Tee from the University of Sheffield, explain building global health with LEGO vaccines.
Figure 1. Two routes of brain infection by which SARS-CoV-2 may enter the hypothalamus and infect GnRH neurons. The virus attaches to and enters cells harbouring surface receptors such as ACE2 (black spanner-like symbol) or NRP1 (red cylinder). GnRH neurons exhibit both, which might increase their vulnerability. A. The haematological route, whereby the respiratory virus (white spheres) makes its way through the lungs into the bloodstream (dark red), and thence into the median eminence (ME), a part of the hypothalamus that harbours ”fenestrated” or leaky blood vessels. The virus may affect a number of different cell types locally, including GnRH neurons (green), whose secretory terminals approach the fenestrated vessels, and tanycytes (grey), whose processes control this secretion and also transport other bloodborne hormones and other substances into the brain. Once inside the brain ventricles (V), fluid-filled canals within the brain, the virus can also travel to other areas. B. The olfactory route, whereby the virus enters the olfactory bulb (OB) of the brain directly from the nose across the bony cribriform plate by means of nerve bundles or infected olfactory neurons and other cell types. GnRH neurons, which are born in the nasal epithelium during the embryonic period and migrate into the brain along these nerve bundles to their final positions, still maintain a connection with their birthplace, and could be thus be infected directly or indirectly through olfactory neurons or other cells. GnRH neurons also project to parts of the brain involved in higher functions such as cognition, potentially contributing to long-COVID symptoms such as “brain fog”.

Brain infection by SARS-CoV-2: Lifelong consequences

The WATCH team, founded to elucidate the role played by specialized brain cells called tanycytes in various physiological processes, has been investigating how and where the SARS-CoV-2 virus infects the brain, and some long-term consequences of this neuro-invasion.
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Understanding the climate change impact on health

Scientists at the Climate Service Center Germany (GERICS) help society to prepare for climate change impacts on health in a multi-faceted approach.
Puppy in countryside

Nutritional management of chronic kidney disease in pets

Renea Creech and Kim Wilson outline the challenges of Chronic Kidney Disease in pets, the irreversible loss of kidney function, and how nutrition can help.
bleached coral under breaking wave

Coral disease has tripled over the last 25 years, wiping out entire reef habitats

As global temperatures rise, deadly coral disease is becoming more prevalent on reefs. Likely to become endemic, researchers highlight the need for urgent mitigation of coral disease.
child being vaccinated against virus

Government urges parents to check for measles vaccine as cases spike in children

The UK government has urged parents to check their children's measles vaccine records due to an increase in virus cases.
Enterobacterias Gram negativas Proteobacteria, bacteria such as salmonella, escherichia coli, yersinia pestis, klebsiella. 3D illustration

RR-TB treatments, testing bedaquiline and injectable kanamycin

Here, Professor Andre Nunn from Medical Research Council Clinical Trials Unit at UCL, explores tuberculosis with a focus on RR-TB treatments (rifampicin-resistant) and their drug combinations.
Human papillomavirus vaccine - administration of antigenic material (vaccine) to stimulate an individual's immune system to develop adaptive immunity to a pathogen.

An HPV factsheet – Everything you need to know

HPV is the most common STI in the world, affecting 80% of the population. Here Dr Deborah Lee, from Dr Fox Online Pharmacy, addresses the most common issues about HPV in an attempt to aid in the understanding of the condition
Gynecologist testing vaginal swab for STD

Taking complexity into account: Public health strategies adaption to the end of the decade

Dr Zisis Kozlakidis and Sandra Nanyonga discuss public health strategies, then and now, with a focus on the prevalence of STDs.

How did past societies handle the impacts of climate change?

Impacts of climate change on past human societies over the past 5000 years offer lessons for current global warming preparation.
treatment for inflammatory bowel disease

Prebiotics from algae as a treatment for inflammatory bowel disease

The Algae4IBD project is studying the potential of probiotics and algae-derived prebiotics as a treatment for inflammatory bowel disease.

Wicked-Schisto: The wicked public health problem of Schistosomiasis and the interdisciplinary research helping to...

Poppy Lamberton, Professor of Global Health at the University of Glasgow, is leading an interdisciplinary team aiming to identify cost-effective, sustainable interventions for schistosomiasis, a devastating neglected tropical disease.
Disease surveillance SACIDS image

Enhancing community-based disease surveillance using Afyadata in Mozambique

SACIDS, in collaboration with the Ministry of Health in Mozambique is capitalizing on its AfyaData, a digital disease surveillance app, to enhance early detection, timely reporting and prompt feedback/response to health-related signals/events, including COVID-19 and other priority diseases in the country.
Scientist in lab with COVID-19 equipment

COVID-19, communicable disease and immunology

Academic Research Scholar, Prof Wendy M. Purcell, provides an update on COVID-19, communicable disease and immunology.
pigs on a farm

Investigating a new method for pig vaccinations

Livestock vaccinations lead to healthy animals, healthy consumers, and a profitable industry.
genomic characterisation, Tanzania

Genomic characterisation for improved responses to dengue outbreaks in Tanzania

Gaspary Mwanyika from the SACIDS Foundation for One Health, Sokoine University of Agriculture, Tanzania details the importance of genomic characterisation in the control of dengue.

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