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Modern Medical Research Laboratory: Portrait of Latin and Black Young Scientists Using Microscope, Digital Tablet, Doing Sample Analysis, Talking. Diverse Team of Specialists work in Advanced Lab

Collaboration and Partnerships in Accelerating Cancer Drug Development

Lorna Rothery spoke to the Cancer Drug Development Forum’s Managing Director, Professor Jaap Verweij and Chairperson of the CDDF Board of Directors, Professor Ruth Plummer, about opportunities and challenges in oncology research and treatment.

Are over-the-counter drugs an under-appreciated toxic danger?

OTC drugs are not harmless. Understanding the effects and dangers of OCT abuse and misuse is key to public safety, here UC Davis explains

Medical abrasion phenomenon as a cause of knee osteoarthritis

Professor Shaw-Ruey Lyu from Tzu-Chi University tells us how the discovery of the medial abrasion phenomenon, as a cause of knee osteoarthritis, has changed how it is best treated.

Engineered endosymbionts as novel cancer therapeutics

Satyajit Hari Kulkarni and Christopher H. Contag from the Institute for Quantitative Health Science and Engineering focus on engineered endosymbionts, which they argue is a paradigm shift in anticancer bacteriotherapy toward killing tumors from the inside out.

AI unlocks cancer treatment secrets

Using artificial intelligence, scientists have tackled one of the toughest challenges in cancer research.
Knee Health Promotion Option

Knee health promotion option: A comprehensive management for knee osteoarthritis

Knee pain and knee osteoarthritis degrade the quality of life of sufferers. Drawing from our clinical experience and research, we have identified ‘hidden lesions’ of knee osteoarthritis (knee OA) and scrutinized the role of medial abrasion phenomenon (MAP) in the pathogenesis of knee OA.
Mature woman brushing her hair at home

How does our diet and lifestyle affect our hair growth?

According to hair stylists, 68% of women are unhappy about their hair. How women feel about our hair correlates strongly with our feelings. The most common complaints are that our hair is 'too dry', 'it's falling out', or it 'grows too slowly'.

The European Revert Project: Assisting clinicians in patient treatment

Starting in January 2020, the European REVERT project is now in its final phase. The project blends predictive medicine and AI to enable clinicians to quickly and adequately treat patients.
60 year old prisoner with a beard communicates with his son through glass during a visitation

Offender-led religious movements: Why we should have faith in prisoner-led reform

Byron R. Johnson and Sung Joon Jang, both from Baylor University and Pepperdine University, suggest that the solution to criminal justice reform could lie in the prisoner-led faith programmes, which provide positive, cost-efficient rehabilitation.
Cancer cells in human body, conceptual 3d illustration

Unraveling the potential of antisense therapies to target neuropilin 1 in the fight against...

Secarna Pharmaceuticals, the next-generation antisense drug discovery and development company, is developing novel approaches to successfully target Neuropilin 1 (NRP1), a promising target for the treatment of cancer.
Mature man helps younger man verbalize problems in therapy

Breaking the stigma: Men’s mental health matters

Dr Deborah Lee from Dr Fox Online Pharmacy discusses men’s mental health, including common barriers to seeking help and the measures needed to improve overall awareness and support.
Stem cells, cancer survival rates

Secarna aims to expand the therapeutic toolbox against cancer

Current oncology treatments have significantly improved cancer survival rates, but more effective and safer therapeutics are needed.
Figure 1. Two routes of brain infection by which SARS-CoV-2 may enter the hypothalamus and infect GnRH neurons. The virus attaches to and enters cells harbouring surface receptors such as ACE2 (black spanner-like symbol) or NRP1 (red cylinder). GnRH neurons exhibit both, which might increase their vulnerability. A. The haematological route, whereby the respiratory virus (white spheres) makes its way through the lungs into the bloodstream (dark red), and thence into the median eminence (ME), a part of the hypothalamus that harbours ”fenestrated” or leaky blood vessels. The virus may affect a number of different cell types locally, including GnRH neurons (green), whose secretory terminals approach the fenestrated vessels, and tanycytes (grey), whose processes control this secretion and also transport other bloodborne hormones and other substances into the brain. Once inside the brain ventricles (V), fluid-filled canals within the brain, the virus can also travel to other areas. B. The olfactory route, whereby the virus enters the olfactory bulb (OB) of the brain directly from the nose across the bony cribriform plate by means of nerve bundles or infected olfactory neurons and other cell types. GnRH neurons, which are born in the nasal epithelium during the embryonic period and migrate into the brain along these nerve bundles to their final positions, still maintain a connection with their birthplace, and could be thus be infected directly or indirectly through olfactory neurons or other cells. GnRH neurons also project to parts of the brain involved in higher functions such as cognition, potentially contributing to long-COVID symptoms such as “brain fog”.

Brain infection by SARS-CoV-2: Lifelong consequences

The WATCH team, founded to elucidate the role played by specialized brain cells called tanycytes in various physiological processes, has been investigating how and where the SARS-CoV-2 virus infects the brain, and some long-term consequences of this neuro-invasion.
Psoriasis biopsy

Understanding psoriasis: Symptoms, causes, and treatments

Psoriasis is a chronic immune-mediated inflammatory disease that can impact sufferers’ mental and physical health. We discuss the complexity of the condition as well as the emergence of effective treatments with the national UK charity The Psoriasis Association.
Cropped shot of a senior woman holding hands with a nurse

Addressing ageism in healthcare through gerontological nursing

Sherry Dahlke, Associate Professor at the Faculty of Nursing, University of Alberta, discusses the impact of ageism in healthcare and why gerontological nursing education is vital for improving awareness and patient care.
Tumor microenvironment concept with cancer cells, T-Cells, nanoparticles, cancer associated fibroblast layer of tumor microenvironment normal cells, molecules, and blood vessels 3d rendering

Understanding T lymphocytes inner workings to harness therapeutic potential

Leslie J. Berg, PhD from the University of Colorado, Anschutz School of Medicine, sheds light on understanding the inner workings of T lymphocytes to harness their therapeutic potential.
Elderly Man Inserting His Hearing Aid

Hearing loss: Ageing and noise exposure are the two major causes

Dr Tracey Pollard from RNID, the charity which supports the 12 million people in the UK who are deaf, have hearing loss or tinnitus, talks us through the causes and impact of hearing loss and how RNID is working to improve research and related treatments in this field.
3D render of a medical background with virus cells, rare diseases

Overcoming the ongoing challenges for rare disease patients in the UK

Gillian Molloy, Director of Market Access at AscellaHealth, examines the rare disease landscape in the UK, including progress in improving patient care and challenges in diagnostics and the development of new treatments.
People, health care and problem concept - unhappy mid adult man suffering from knee ache at home

Understanding osteoarthritis: Causes, symptoms, and treatment options

With ten million people in the UK alone suffering from osteoarthritis, Dr Deborah Lee explains the prevalence of the condition, the common risk factors, and preventative measures.
Old woman in bed looking at screen of laptop and consulting with a doctor online at home, telehealth

The future of healthcare: Exploring the benefits of virtual wards

The Health Tech Alliance explains the importance of digital and technological innovations, particularly virtual wards, in supporting NHS healthcare providers.

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