Revolutionary brain-computer interface gives voice to ALS patients

Microchip is implanted in human brain. Neural implants. Brain-computer interface. Neuron technology concept - illustration
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Scientists at UC Davis Health have unveiled a cutting-edge brain-computer interface (BCI) that translates brain signals into speech with an astounding 97% accuracy

This achievement marks a significant leap forward in assisting individuals with severe speech impairments, such as those caused by amyotrophic lateral sclerosis (ALS).

Published today in the prestigious New England Journal of Medicine, the study showcases how the BCI enabled a man suffering from advanced ALS to communicate his thoughts within minutes of activation.

Restoring essential communication abilities

This new technology promises to restore essential communication abilities for people incapacitated by paralysis or neurological conditions.

The participant in this pioneering research is Casey Harrell, a 45-year-old with ALS, a disease notorious for gradually robbing individuals of their ability to move and speak. Harrell, before the trial, faced extreme difficulty in articulating understandable speech, relying heavily on others to interpret his intentions.

Dr. David Brandman, co-principal investigator of the study and a prominent neurosurgeon at UC Davis, implanted four microelectrode arrays into Harrell’s brain in July 2023. These arrays, positioned in the left precentral gyrus responsible for speech coordination, captured brain activity from 256 cortical electrodes. The BCI then decoded these neural patterns into text, which a computer vocalised aloud in a voice resembling Harrell’s pre-ALS speech.

“This technology is transformative because it provides hope for people who want to speak but can’t,” remarked Dr. Brandman. ” I hope that technology like this speech BCI will help future patients speak with their family and friends.”

Learning basic vocabulary

The system’s efficacy was evident from early trials, where after just 30 minutes of training, it achieved a 99.6% accuracy with a basic vocabulary. Sessions expanded the vocabulary to 125,000 words with an impressive 97.5% accuracy rate, showcasing the system’s adaptability and reliability in real-time communication scenarios.

The future of BCI technology

The study’s lead author, Nicholas Card, emphasised the altruism of participants like Harrell, who contribute to advancing medical science not for personal gain but to benefit others with similar challenges.

Looking ahead, the researchers envision broader applications for this BCI technology, including enhancing mobility and independence for individuals with severe disabilities. The BrainGate2 clinical trial, overseen by Dr. Brandman, continues to enrol participants, promising further innovations in neuroprosthetics.

The success of this study represents a beacon of hope for individuals whose voices have been silenced by neurological conditions. As technology continues to evolve, so too does the potential to transform lives, offering newfound freedom and dignity to those in need.

For more information on the study and ongoing clinical trials, visit BrainGate.org.

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