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Fig. 1 White matter hyperintensities (illustrated in blue) in a representative image of the human brain (A) are primarily found near ventricles. The neuronal cell bodies are found mainly in the cortex (gray matter) and myelinated neuronal axons in the white matter (B). Figure created using BioRender.

What is the link between white matter lesions and neurodegeneration?

Tara M. DeSilva from the Department of Neurosciences, Cleveland Clinic, examines the link between white matter lesions and neurodegeneration.
Figure 1: Immunomodulatory therapies are effective during the relapsing-remitting phase of MS, when immune cells are found in active lesions, but fail to ameliorate progressive decline and irreversible clinical disability. Increased axonal injury correlates with lack of immune cell infiltration but sustained activation of resident CNS glial cells in the progressive phase. These pathological findings are consistent with MRI imaging studies demonstrating virtually no new lesions occurring during progressive MS. Additionally, at the time of MS diagnosis there is evidence of prior lesion activity by MRI imaging supporting that the future development of neuroprotective strategies should be administered in combination with immunomodulatory therapies.

Targeting the central nervous system: The future of therapeutic strategies for MS

Tara M. DeSilva from the Department of Neurosciences, Cleveland Clinic, looks at the future of therapeutic strategies for MS, focusing on targeting the central nervous system.

Remyelinating versus neuroprotective therapies for multiple sclerosis

Reducing clinical relapses and improving quality of life is at the heart of MS treatment; here Tara M. DeSilva explores the benefits of remyelinating versus neuroprotective therapies for tackling MS.
neurodegeneration

Neurodegeneration in multiple sclerosis: retinal imaging as a biomarker

Therapeutic strategies for multiple sclerosis reduce the number of relapses and improve quality of life early in the disease course, nevertheless, neurodegeneration ultimately gives rise to permanent disability.

Regenerative therapies for multiple sclerosis: Clues from studying normal brain development

Tara M. DeSilva from the Department of Neurosciences, Cleveland Clinic, walks us through regenerative therapies for multiple sclerosis, including comment on clues from studying normal brain development.

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