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Targeting the endocannabinoid system

Targeting the endocannabinoid system: A promising hope for the treatment of Inflammatory bowel Disease...

Current IBD treatments leave many battling uncomfortable symptoms. The bodies natural endocannabanoid system (ECS) is linked to gut health. By targeting the system, researchers believe they will be able to develop novel treatments that tackle inflammation, diarrhea and lingering discomfort. By focusing on this, researchers believe they will be able to develop treatments that tackle both inflammation and lingering discomfort.
Figure 1: Beneficial effects of Kinase inhibition for multiple indications

Protein kinases for combating inflammatory disease

Julie Blaising, Discovery Project Leader in Immunology at F. Hoffmann-La Roche Ltd, tells us why protein kinases are an effective target for treating many chronic inflammatory disorders.
Roche

Roche – biotechnology and in-vitro diagnostics

Roche is a leading provider of in-vitro diagnostics and a global supplier of transformative innovative solutions across major disease areas.
Figure 1: Abnormal pain response in IBD and Endometriosis.

Therapeutic potential of the endocannabinoid system to treat chronic pain in inflammatory disease

Pharma researchers Julie Blaising and Philip Smith from F. Hoffmann-La Roche Ltd. discuss the endocannabinoid system as a pathway to treat inflammatory diseases such as Inflammatory Bowel Disease (IBD) and endometriosis.

MAGL inhibition: A novel treatment option for combating inflammatory disease?

Pharma researchers Uwe Grether and Julie Blaising from F. Hoffmann-La Roche Ltd. highlight the vast therapeutic potential of MAGL inhibition for central and peripheral diseases.
Figure 1: Scientific innovations in ECS research and drug discovery that will strongly impact the future discovery of improved and tailor-made CB2R medicines.

CB₂R ligands to treat inflammatory diseases

Researchers discuss how scientific innovations might influence the discovery of future tailor-made CB2R-based anti-inflammatory treatments.
Inflammation concept, inflamed human tissues 3d rendering.

CB2R agonists in the clinics: A treasure chest for treating inflammatory diseases

Researchers give an update on clinical trials with CB2R agonists and their potential for the treatment of inflammatory diseases.
Targeting the Cannabinoid Type-2 Receptor for Novel Anto-inflammatory Therapeutics

Targeting the Cannabinoid Type-2 Receptor for Novel Anto-inflammatory Therapeutics

Type-2 cannabinoid receptor (CB2R) is a G-protein-coupled receptor (GPCR) and an essential element of the endocannabinoid system (ECS) [1].
Densely packed cannabis plants under LED lights at large scale industrial growing operation.

Visualizing the anti-inflammatory cannabinoid Type-2 receptor

Medicinal chemists describe how small molecule probes allow for the detection of CB2R, and thereby enable the discovery of novel anti-inflammatory treatments.
cannais plants

Challenges bringing CB₂R medicine to bedside

Drug hunters explain how to overcome pitfalls on the way to CB2R medicine and therapeutics.
cannabis to treat diseases

Is CB₂R a hidden treasure trove for treating inflammatory diseases?

Expert scientists working on endocannabinoid system (ECS) trials explain how CB₂R can be used to treat inflammatory diseases.

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