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FIGURE 1 shows the basic steps required to obtain genetic phase or haplotyping for the HLA system in a potential bone marrow transplant recipient without resorting to family studies. Studies to date have shown superior outcomes in haplotype-matched recipient/donor pairs compared to those matched for individual alleles at multiple HLA loci. (Kitcharoen, Petersdorf, Maskalana)

Single chromosome sequencing to obtain genetic phase (haplotyping)

Brian Tait, Chief Scientific Officer at Haplomic Technologies Pty Ltd, examines single chromosome sequencing to obtain genetic phase (haplotyping).

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