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Arc: A therapeutic hub for Alzheimer's disease

Arc: A therapeutic hub for Alzheimer’s disease

Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by progressive memory loss and cognitive impairments. Therapy development has been driven almost exclusively by the amyloid hypothesis, which poses that AD is caused by the amyloid plaques seen in postmortem brains of patients. However, drugs targeting amyloid plaques have failed to show efficacy in clinical trials. A new approach is needed.
Still image of highly dynamic chromatin (red) interacts with Arc pucta (green). Shown is a small detail of a neuronal nucleus imaged by high-resolution microscopy. Notice how finger-like extensions of the chromatin transiently visit Arc pucta. The movie is sped up 10 times.

Arc: A new target for treating alzheimer’s disease

Antonius M. VanDongen, Associate Professor from Duke University, walks us through Arc, a new target for treating Alzheimer’s disease.

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